Browsing by Author "Geßner, Cornelia"

Now showing items 1-3 of 3

    • Elevated antioxidant defence in the brain of deep-diving pinnipeds 

      Martens, Gerrit A.; Folkow, Lars; Burmester, Thorsten; Geßner, Cornelia (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-16)
      While foraging, marine mammals undertake repetitive diving bouts. When the animal surfaces, reperfusion makes oxygen readily available for the electron transport chain, which leads to increased production of reactive oxygen species and risk of oxidative damage. In blood and several tissues, such as heart, lung, muscle and kidney, marine mammals generally exhibit an elevated antioxidant defence. ...

    • The roles of brain lipids and polar metabolites in the hypoxia tolerance of deep-diving pinnipeds 

      Martens, Gerrit A.; Geßner, Cornelia; Folkow, Lars; Creydt, Marina; Fischer, Markus; Burmester, Thorsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-14)
      Lipids make up more than half of the human brain's dry weight, yet the composition and function of the brain lipidome is not well characterized. Lipids not only provide the structural basis of cell membranes, but also take part in a wide variety of biochemical processes. In neurodegenerative diseases, lipids can facilitate neuroprotection and serve as diagnostic biomarkers. The study of organisms ...

    • Transcriptomes Suggest That Pinniped and Cetacean Brains Have a High Capacity for Aerobic Metabolism While Reducing Energy-Intensive Processes Such as Synaptic Transmission 

      Geßner, Cornelia; Krüger, Alena; Folkow, Lars; Fehrle, Wilfrid; Mikkelsen, Bjarni; Burmester, Thorsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-09)
      The mammalian brain is characterized by high energy expenditure and small energy reserves, making it dependent on continuous vascular oxygen and nutritional supply. The brain is therefore extremely vulnerable to hypoxia. While neurons of most terrestrial mammals suffer from irreversible damage after only short periods of hypoxia, neurons of the deep-diving hooded seal (Cystophora cristata) show ...